PhronesisCancer is the most extensively studied biological displacement phenomenon, with approximately 20 million new cases annually worldwide who2022. We present a comprehensive treatment of cancer biology organized entirely through the displacement framework, proposing that malignant transformation is the progressive displacement of somatic cells from their multicellular ground state toward an ancestral single-cell metabolic configuration.
Each hallmark of cancer identified by Hanahan and Weinberg hanahan2011 is reinterpreted as a specific displacement marker: a measurable deviation from along a defined biological axis. The Warburg effect --- aerobic glycolysis in oxygen-rich conditions --- is identified as the metabolic signature of this reversion, extending the account in Rinc\'on, alice, \& cl\"oe rincon2026cancer.
The tumor microenvironment, immune evasion, genetic instability, and metastasis are each treated as secondary displacements compounding the primary somatic displacement. Treatment modalities are evaluated by their capacity to reduce total displacement and restore, rather than by tumor size reduction alone. Environmental forcing --- including plastic body burden from PFAS and endocrine disruptors rincon2026plas --- is identified as an exogenous component of the somatic displacement trajectory.