PhronesisWe apply the Displacement Framework to Celiac Disease, formalizing it around the concept of radical ground state redefinition — a case in which the therapeutic goal is not restoration of the original ground state but permanent redefinition of the achievable ground state to exclude a specific environmental trigger. The intestinal ground state S⁰_intestinal is defined across five dimensions including unrestricted dietary landscape; in celiac disease, this fifth dimension is permanently excluded, and S⁰_GFD (the gluten-free dietary ground state) becomes the only achievable S⁰.
Gluten ingestion triggers HLA-DQ2/DQ8-mediated immune activation → CD4+ T cell response → villous atrophy (Marsh III) → malabsorption D(ξ) cascade. Nine formal propositions are derived covering: S⁰_intestinal definition with mandatory exclusion of gluten (P1), gluten as permanent environmental D(ξ) trigger rather than wrong attractor (P2), the S⁰ redefinition argument — no return to dietary-unrestricted S⁰ exists (P3), the GFD as new landscape with permanent vigilance requirement and D(ξ_contamination) (P4), non-responsive celiac as incomplete landscape modification and RCD-II as deep wrong attractor with EATL malignancy risk (P5), multi-domain Φ accumulation across nutritional, skeletal, neurological, reproductive, and oncological domains (P6), the underdiagnosis problem (80% globally undiagnosed, 6-10 year diagnostic delay as pre-treatment Φ accumulation) (P7), formal distinction of celiac from non-celiac gluten sensitivity (no autoimmune mechanism, no villous atrophy) and wheat allergy (P8), and emerging therapies (glutenases, tTG inhibitors, tolerization) as future genuine return-path alternatives to permanent exclusion (P9).