PhronesisWe apply the Displacement Framework to immune aging (immunosenescence), formalizing the age-related erosion of immune competence as progressive displacement from a seven-component ground state S0_immune. Eight formal propositions are derived covering: thymic involution as naive T cell reserve depletion (ODE for diversity decline), inflammaging as accumulated immune displacement Phi_immune from five self-reinforcing sources, senescence-associated secretory phenotype (SASP) as a self-reinforcing wrong attractor with bystander senescence loop, CMV-driven clonal inflation as repertoire displacement ratchet, and vaccine immunogenicity failure as direct clinical readout of accumulated Phi_immune.
Three return-path propositions cover caloric restriction as displacement-rate reduction, senolytics (dasatinib+quercetin) as SASP wrong-attractor exit, and rapamycin/mTOR inhibition as thymic partial recovery. A 10-row summary table maps all immunosenescence phenomena to Displacement Framework objects.