Insulin Resistance as Signal Deafness: Cellular Return Failure, Metabolic Wrong-Attractor Cascade, and the Ground State of Glucose Homeostasis

We apply the Displacement Framework to insulin resistance and metabolic syndrome, formalizing insulin as the body's primary metabolic return signal and insulin resistance as signal deafness — the return signal is sent but the cellular receiver is impaired. The metabolic ground state S0_metabolic is defined across fasting glucose, insulin sensitivity (HOMA-IR), lipid profile, and beta-cell function.

Six formal propositions are derived covering insulin as canonical return signal, resistance as IRS-1 serine phosphorylation-mediated signal deafness, the vicious cycle of hyperinsulinemia and receptor downregulation, beta-cell exhaustion as irreversible wrong-attractor entry, metabolic syndrome as compounding cross-coupled wrong attractor (positive dominant eigenvalue of the coupling Jacobian), and whole-food plant-based diet as multi-path return strategy targeting ceramide reduction, gut microbiome optimization, and AMPK activation.